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Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer.
Li, Jing; Ohmura, Shunya; Marchetto, Aruna; Orth, Martin F; Imle, Roland; Dallmayer, Marlene; Musa, Julian; Knott, Maximilian M L; Hölting, Tilman L B; Stein, Stefanie; Funk, Cornelius M; Sastre, Ana; Alonso, Javier; Bestvater, Felix; Kasan, Merve; Romero-Pérez, Laura; Hartmann, Wolfgang; Ranft, Andreas; Banito, Ana; Dirksen, Uta; Kirchner, Thomas; Cidre-Aranaz, Florencia; Grünewald, Thomas G P.
Afiliación
  • Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Ohmura S; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Marchetto A; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
  • Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Imle R; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Dallmayer M; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
  • Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Hölting TLB; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
  • Stein S; Soft tissue sarcoma Junior Research Group, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Funk CM; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Sastre A; Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Alonso J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Bestvater F; Department of General Pediatrics, University Hospital Münster, Münster, Germany.
  • Kasan M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Romero-Pérez L; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Hartmann W; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
  • Ranft A; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Banito A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Dirksen U; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Kirchner T; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Grünewald TGP; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Nat Commun ; 12(1): 5356, 2021 09 16.
Article en En | MEDLINE | ID: mdl-34531368
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sarcoma de Ewing / Proteínas de Fusión Oncogénica / Proteínas Proto-Oncogénicas / Proteínas Serina-Treonina Quinasas / Apoptosis / Proteínas de Ciclo Celular Tipo de estudio: Prognostic_studies Límite: Animals / Child / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sarcoma de Ewing / Proteínas de Fusión Oncogénica / Proteínas Proto-Oncogénicas / Proteínas Serina-Treonina Quinasas / Apoptosis / Proteínas de Ciclo Celular Tipo de estudio: Prognostic_studies Límite: Animals / Child / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania