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Exposure-response analysis of acalabrutinib and its active metabolite, ACP-5862, in patients with B-cell malignancies.
Edlund, Helena; Buil-Bruna, Núria; Vishwanathan, Karthick; Wei, Helen; Raman, Rakesh; de Kock, Miné; He, Zhongqing; Liu, Huan; Baek, Marshall; Ware, Joseph; Patel, Priti; Tomkinson, Helen; Sharma, Shringi.
Afiliación
  • Edlund H; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Buil-Bruna N; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Vishwanathan K; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Boston, Massachusetts, USA.
  • Wei H; Biostatistics, AstraZeneca, South San Francisco, California, USA.
  • Raman R; Medical Safety Science, AstraZeneca, South San Francisco, California, USA.
  • de Kock M; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • He Z; Quantitative Clinical Pharmacology Data Services, R&D, AstraZeneca, Boston, Massachusetts, USA.
  • Liu H; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Boston, Massachusetts, USA.
  • Baek M; Biostatistics, AstraZeneca, South San Francisco, California, USA.
  • Ware J; Quantitative Clinical Pharmacology, AstraZeneca, South San Francisco, California, USA.
  • Patel P; Clinical Development, AstraZeneca, South San Francisco, California, USA.
  • Tomkinson H; Clinical Pharmacology & Quantitative Pharmacology (CPQP), Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Sharma S; Quantitative Clinical Pharmacology, AstraZeneca, South San Francisco, California, USA.
Br J Clin Pharmacol ; 88(5): 2284-2296, 2022 05.
Article en En | MEDLINE | ID: mdl-34532877
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B Límite: Humans Idioma: En Revista: Br J Clin Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Suecia
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B Límite: Humans Idioma: En Revista: Br J Clin Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Suecia