Establishment and application of population pharmacokinetics model of vancomycin in infants with meningitis.
Pediatr Neonatol
; 63(1): 57-65, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34544677
ABSTRACT
BACKGROUND:
To establish a population pharmacokinetics (PPK) model of vancomycin (VCM) for dose individualization in Chinese infants with meningitis.METHODS:
We collected the data of 82 children with meningitis in hospital from July 2014 to June 2016. The initial vancomycin dosage regimen for children was 10 or 15 mg/kg for q12 h, q8 h or q6 h. Serum concentrations were determined by Viva-E Analyzer before and after the fifth administration. The PPK model was developed by nonlinear mixed-effect model software, assessed by the bootstrap method and then tested in 20 infant patients.RESULTS:
The VCM clearance (CL) was increased by body weight (WT) and decreased by blood urea nitrogen (BUN). Pharmacokinetic parameters of VCM were not influenced by co-administered drugs. The trough concentrations of VCM were accurately predicted by the PPK model, with the prediction errors less than 32%.CONCLUSION:
A new individual strategy for VCM regimens was proposed and validated by the PPK model.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vancomicina
/
Meningitis
Tipo de estudio:
Prognostic_studies
Límite:
Child
/
Humans
/
Infant
Idioma:
En
Revista:
Pediatr Neonatol
Año:
2022
Tipo del documento:
Article
País de afiliación:
China