Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.
Nat Commun
; 12(1): 5530, 2021 09 20.
Article
en En
| MEDLINE
| ID: mdl-34545083
ABSTRACT
Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Amplificación de Genes
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Inhibidor p16 de la Quinasa Dependiente de Ciclina
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Receptor alfa de Factor de Crecimiento Derivado de Plaquetas
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Inhibidor p15 de las Quinasas Dependientes de la Ciclina
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Glioma
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Recurrencia Local de Neoplasia
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Nat Commun
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania