Luminal Fluid Motion Inside an In Vitro Dissolution Model of the Human Ascending Colon Assessed Using Magnetic Resonance Imaging.

O'Farrell, Connor; Hoad, Caroline L; Stamatopoulos, Konstantinos; Marciani, Luca; Sulaiman, Sarah; Simmons, Mark J H; Batchelor, Hannah K

O'Farrell, Connor; Hoad, Caroline L; Stamatopoulos, Konstantinos; Marciani, Luca; Sulaiman, Sarah; Simmons, Mark J H; Batchelor, Hannah K.

Afiliación

O'Farrell C; School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UK.
Hoad CL; Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham NG7 2RD, UK.
Stamatopoulos K; National Institute for Health Research (NIHR), Nottingham Digestive Diseases Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK.
Marciani L; School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UK.
Sulaiman S; Biopharmaceutics, Pharmaceutical Development, PDS, MST, RD Platform Technology & Science, GSK, David Jack Centre, Ware SG12 0DP, Hertfordshire, UK.
Simmons MJH; National Institute for Health Research (NIHR), Nottingham Digestive Diseases Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK.
Batchelor HK; National Institute for Health Research (NIHR), Nottingham Digestive Diseases Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK.

Pharmaceutics ; 13(10)2021 Sep 23.

Article en En | MEDLINE | ID: mdl-34683837

Palabras clave

MR tagging; colon; colon-specific drug formulations; colonic flow; colonic mixing; dynamic colon model (DCM); large intestine; phase contrast cine-MRI

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido