Regulation of FGF23: Beyond Bone.
Curr Osteoporos Rep
; 19(6): 563-573, 2021 12.
Article
en En
| MEDLINE
| ID: mdl-34757587
ABSTRACT
PURPOSE OF REVIEW Fibroblast growth factor 23 (FGF23) is a bone- and bone marrow-derived hormone that is critical to maintain phosphate homeostasis. The principal actions of FGF23 are to reduce serum phosphate levels by decreasing kidney phosphate reabsorption and 1,25-dihydroxyvitamin D synthesis. FGF23 deficiency causes hyperphosphatemia and ectopic calcifications, while FGF23 excess causes hypophosphatemia and skeletal defects. Excess FGF23 also correlates with kidney disease, where it is associated with increased morbidity and mortality. Accordingly, FGF23 levels are tightly regulated, but the mechanisms remain incompletely understood. RECENT FINDINGS:
In addition to bone mineral factors, additional factors including iron, erythropoietin, inflammation, energy, and metabolism regulate FGF23. All these factors affect Fgf23 expression, while some also regulate FGF23 protein cleavage. Conversely, FGF23 may have a functional role in regulating these biologic processes. Understanding the bi-directional relationship between FGF23 and non-bone mineral factors is providing new insights into FGF23 regulation and function.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Metabolismo Energético
/
Eritropoyesis
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Factor-23 de Crecimiento de Fibroblastos
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Deficiencias de Hierro
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Inflamación
Límite:
Animals
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Humans
Idioma:
En
Revista:
Curr Osteoporos Rep
Asunto de la revista:
ORTOPEDIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos