Perifosine, a Bioavailable Alkylphospholipid Akt Inhibitor, Exhibits Antitumor Activity in Murine Models of Cancer Brain Metastasis Through Favorable Tumor Exposure.

Taniguchi, Keisuke; Suzuki, Tomo; Okamura, Tomomi; Kurita, Akinobu; Nohara, Gou; Ishii, Satoru; Kado, Shoichi; Takagi, Akimitsu; Tsugane, Momomi; Shishido, Yoshiyuki

Taniguchi, Keisuke; Suzuki, Tomo; Okamura, Tomomi; Kurita, Akinobu; Nohara, Gou; Ishii, Satoru; Kado, Shoichi; Takagi, Akimitsu; Tsugane, Momomi; Shishido, Yoshiyuki.

Afiliación

Taniguchi K; Yakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan.
Suzuki T; Yakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan.
Okamura T; Yakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan.
Kurita A; Yakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan.
Nohara G; Pharmaceutical Research & Development Department, Yakult Honsha Co., Ltd., Tokyo, Japan.
Ishii S; Pharmaceutical Research & Development Department, Yakult Honsha Co., Ltd., Tokyo, Japan.
Kado S; Yakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan.
Takagi A; Yakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan.
Tsugane M; Yakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan.
Shishido Y; Yakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan.

Front Oncol ; 11: 754365, 2021.

Article en En | MEDLINE | ID: mdl-34804943

Palabras clave

AKT; PI3K; apoptosis; brain cancer; metastasis; signaling pathway

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2021 Tipo del documento: Article País de afiliación: Japón