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Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery.
Sogawa-Fujiwara, Chizuru; Fujiwara, Yasuhiro; Hanagata, Atsuki; Yang, Qunhui; Mihara, Taiki; Kaji, Noriyuki; Kunieda, Tetsuo; Hori, Masatoshi.
Afiliación
  • Sogawa-Fujiwara C; Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan. chizuru.f.sogawa@gmail.com.
  • Fujiwara Y; Laboratory of Pathology and Development, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
  • Hanagata A; Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
  • Yang Q; Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
  • Mihara T; Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
  • Kaji N; Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
  • Kunieda T; Faculty of Veterinary Medcine, Okayama University of Science, 1-3 Ikoino-oka, Imabari, Ehime, 794-8555, Japan.
  • Hori M; Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
BMC Res Notes ; 14(1): 438, 2021 Nov 27.
Article en En | MEDLINE | ID: mdl-34838130
OBJECTIVE: The biological importance for the signaling of C-type natriuretic peptide (CNP) and natriuretic peptide receptor B (NPR-B) has been recognized. However, the details remain unclear and are debatable. The Npr2 is a gene of NPR-B, and we previously reported a unique phenotype of a spontaneous mutant mouse lacking Npr2 (Npr2slw/slw), such as severe ileus-like disorder with bloodless blood vessels. In this study, we analyzed the bloodless mesenteric vascular morphology of Npr2slw/slw by histological observation to clarify the effects of the CNP/NPR-B signal deficiency. RESULTS: Blood vessels in the mesentery were clearly dilated in the preweaning Npr2slw/slw mice. Additionally, in the Npr2slw/slw mice, the lacteals were partially dilation or randomly direction mucosal epithelial cells in villi, and mesenteric adipocytes were undeveloped. These findings provide important information for understanding the role of CNP/NPR-B signals on intestine with mesentery.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Vasodilatación / Péptido Natriurético Tipo-C Límite: Animals Idioma: En Revista: BMC Res Notes Año: 2021 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Vasodilatación / Péptido Natriurético Tipo-C Límite: Animals Idioma: En Revista: BMC Res Notes Año: 2021 Tipo del documento: Article País de afiliación: Japón