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Primary breast lymphoma of childhood: a case report and review of literature.
Restivo, Giulia A; Pillon, Marta; Mussolin, Lara; Mosa, Clara; Guarina, Angela; Trizzino, Angela; Ialuna, Salvatore; Carraro, Elisa; D'Amore, Emanuele S G; Russo, Giovanna; Elia, Caterina; Mascarin, Maurizio; Zangara, Adriana; D'Angelo, Paolo; Farruggia, Piero.
Afiliación
  • Restivo GA; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, Italy.
  • Pillon M; Clinic of Pediatric Hemato-Oncology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
  • Mussolin L; Clinic of Pediatric Hemato-Oncology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
  • Mosa C; Institute of Pediatric Research - Fondazione Città della Speranza, Padova, Italy.
  • Guarina A; Department of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, Palermo, Italy.
  • Trizzino A; Department of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, Palermo, Italy.
  • Ialuna S; Department of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, Palermo, Italy.
  • Carraro E; Nuclear Medicine Unit, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.
  • D'Amore ESG; Clinic of Pediatric Hemato-Oncology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
  • Russo G; Department of Pathology, San Bortolo Hospital, Vicenza, Italy.
  • Elia C; Pediatric Hematology and Oncology Unit - AOU Policlinico "Rodolico-San Marco", University of Catania, Catania, Italy. diberuss@unict.it.
  • Mascarin M; AYA Oncology and Pediatric Radiotherapy Unit, CRO - Centro di Riferimento Oncologico di Aviano, IRCCS, Aviano, Italy.
  • Zangara A; AYA Oncology and Pediatric Radiotherapy Unit, CRO - Centro di Riferimento Oncologico di Aviano, IRCCS, Aviano, Italy.
  • D'Angelo P; Radiology Unit, Radiology Department, A.R.N.A.S. Ospedali Civico, Di Cristina e Benfratelli, Palermo, Italy.
  • Farruggia P; Department of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, Palermo, Italy.
BMC Pediatr ; 21(1): 530, 2021 11 30.
Article en En | MEDLINE | ID: mdl-34847896
ABSTRACT

BACKGROUND:

Primary breast lymphoma (PBL) is an extremely rare neoplasm in children; by definition, it manifests in the breast without evidence of lymphoma elsewhere, except ipsilateral axillary nodes. CASE PRESENTATION We report a case of a 15-year-old girl diagnosed with diffuse large B-cell lymphoma (DLBCL) of the right breast the patient received chemotherapy and rituximab, achieving complete remission. A literature review revealed other 11 cases of pediatric PBL; it mainly affects female adolescents and can involve right and left breast equally. Different histologic subtypes have been described, arising from both B-cell and T-cell. Therapeutic approaches were very different, from chemotherapy to local treatment with surgery and/or radiotherapy.

CONCLUSIONS:

Our case is the first in which rituximab was administered, suggesting to be a promising therapy in B-cell PBL, as already demonstrated in pediatric B-cell lymphoma from other sites. Further investigations are needed to identify prognostic factors and establish the most effective treatment.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Linfoma de Células B Grandes Difuso Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Adolescent / Child / Female / Humans Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Linfoma de Células B Grandes Difuso Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Adolescent / Child / Female / Humans Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Italia