A systematic review of maternal TORCH serology as a screen for suspected fetal infection.
Prenat Diagn
; 42(1): 87-96, 2022 Jan.
Article
en En
| MEDLINE
| ID: mdl-34893980
ABSTRACT
BACKGROUND:
The acronym 'TORCH' refers to well-recognised causes of perinatal infections toxoplasmosis, rubella, cytomegalovirus (CMV) and herpes simplex virus (HSV). A TORCH serology panel is often used to test for maternal primary infection following detection of ultrasound abnormalities in pregnancy.AIM:
This review aims to estimate the diagnostic yield of maternal TORCH serology in pregnancy following fetal ultrasound abnormalities. MATERIALS ANDMETHODS:
Primary studies published since 2000 that assessed maternal TORCH serology for suspected fetal infection and included information on indications for testing, definition of positive TORCH serology results, and perinatal outcomes were included.RESULTS:
Eight studies with a total of 2538 pregnancies were included. The main indications for testing were polyhydramnios, fetal growth restriction and hyperechogenic bowel. There were 26 confirmed cases of congenital CMV, of which 15 had multiple ultrasound abnormalities. There were no cases of congenital toxoplasmosis, rubella or HSV confirmed in any of the eight studies.CONCLUSIONS:
The clinical utility of TORCH serology for non-specific ultrasound abnormalities such as isolated fetal growth restriction or isolated polyhydramnios is low. It is time to retire the TORCH acronym and the reflex ordering of 'TORCH' panels, as their continued use obscures, rather than illuminates, appropriate investigation for fetal ultrasound abnormalities.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Serología
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Feto
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Infecciones
Tipo de estudio:
Diagnostic_studies
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Systematic_reviews
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Prenat Diagn
Año:
2022
Tipo del documento:
Article
País de afiliación:
Australia