"P2RY8-son" break of tolerance promotes SLE.
J Exp Med
; 219(1)2022 01 03.
Article
en En
| MEDLINE
| ID: mdl-34901992
In this issue of JEM, He et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211004) associate novel P2RY8 genetic variants to lupus, expanding the field of monogenic autoimmunity. The authors demonstrate that P2RY8 prevents the expansion of DNA-reactive B cells by restraining B cell mobility and activation within the germinal center.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Centro Germinal
/
Lupus Eritematoso Sistémico
Límite:
Humans
Idioma:
En
Revista:
J Exp Med
Año:
2022
Tipo del documento:
Article
País de afiliación:
Francia