Application of adipose-derived stem cells in treating fibrosis.
World J Stem Cells
; 13(11): 1747-1761, 2021 Nov 26.
Article
en En
| MEDLINE
| ID: mdl-34909121
ABSTRACT
Fibrosis is the hyperactivation of fibroblasts that results in excessive accumulation of extracellular matrix, which is involved in numerous pathological changes and diseases. Adipose-derived stem cells (ASCs) are promising seed cells for regenerative medicine due to their bountiful source, low immunogenicity and lack of ethical issues. Their anti-fibrosis, immunomodulation, angiogenesis and other therapeutic effects have made them suitable for treating fibrosis-related diseases. Here, we review the literature on ASCs treating fibrosis, elaborate and discuss their mechanisms of action, changes in disease environment, ways to enhance therapeutic effects, as well as current preclinical and clinical studies, in order to provide a general picture of ASCs treating fibrotic diseases.
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Bases de datos:
MEDLINE
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En
Revista:
World J Stem Cells
Año:
2021
Tipo del documento:
Article
País de afiliación:
China