Myrrh mixed with silver nanoparticles demonstrates superior antimicrobial activity against Porphyromonas gingivalis compared to myrrh and silver nanoparticles alone.
Saudi Dent J
; 33(8): 890-896, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-34938030
ABSTRACT
INTRODUCTION:
Gingivitis is an oral condition characterized by inflammation and bleeding of the gingiva (gums), largely caused by Porphyromonas gingivalis. Oral hygiene options for controlling P. gingivalis include mouthwash containing Commiphora myrrha (myrrh), which has been shown to be effective against the microbe. Silver nanoparticles (SN) have been studied for their antibacterial effect in different oral health applications, including mouthwash. This was an in vitro laboratory study of the anti-microbial actions of myrrh and SN against P. gingivalis.METHODS:
We compared the anti-microbial properties against P. gingivalis of four solutions a) placebo solution, b) myrrh solution (MS), c) MS mixed with silver nanoparticles (MSN), and d) SN suspension alone. Sixteen agar plates were divided into four groups of four plates, and each group was treated with one of the solutions/suspensions. The solution/suspension was administered on the agar disc diffusion method, and inhibition zones (IZs) were measured after 24 (time 1), 48 (time 2), and 72â¯h (time 3). To characterize MSN and SN, Fourier-transform infrared spectroscopy (FT-IR) was used. UV-Vis spectroscopy and energy dispersive X-ray (EDX) were used to further characterize MSN.RESULTS:
After 24â¯h, the median IZ for the MS plates was 16â¯mm, and the median IZ for MSN plates was 15â¯mm. At time 2, the MS median IZ was 15â¯mm, but the MSN median IZ increased to 18â¯mm, and the interquartile ranges (IQRs) did not overlap. At time 3, the median IZs was similar again, with MSN and MS having IZs of 16â¯mm and 15â¯mm, respectively. SN alone showed no anti-microbial activity.CONCLUSIONS:
Our findings show that MSN displayed superior anti-microbial activity against P. gingivalis compared to MS and SN after 48â¯h of incubation, but not after 24â¯h. Also, the increased anti-microbial activity had ceased by 72â¯h.
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Bases de datos:
MEDLINE
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
Saudi Dent J
Año:
2021
Tipo del documento:
Article
País de afiliación:
Arabia Saudita