Systemic lupus erythematosus reactivation after chemoimmunotherapy in preexisting autoimmune disease.
Tumori
; 108(6): 609-614, 2022 Dec.
Article
en En
| MEDLINE
| ID: mdl-34989254
ABSTRACT
The use of immune checkpoint inhibitors (ICIs) offers new possibilities in modern treatment of many types of cancers. Few data regarding safety and efficacy of ICIs are available, and are mainly from retrospective studies and case reports rather than from clinical trials, in the context of preexisting autoimmune disease, mainly due to the risk of severe toxicity. We present an unexpected life-threatening reactivation of systemic lupus erythematosus after one dose of chemo-immunotherapy with pembrolizumab for oligometastatic non-small-cell lung cancer. We analyze data coming from the published literature in this setting and discuss the risk-benefit balance of immunotherapy in patients with preexisting severe autoimmune disease.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
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Carcinoma de Pulmón de Células no Pequeñas
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Neoplasias Pulmonares
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Lupus Eritematoso Sistémico
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Tumori
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia