Urine ß2-Microglobulin and Retinol-Binding Protein and Renal Disease Progression in IgA Nephropathy.
Front Med (Lausanne)
; 8: 792782, 2021.
Article
en En
| MEDLINE
| ID: mdl-35004762
ABSTRACT
Background:
Tubulointerstitial involvement has been reported to have a decisive influence on the progression of IgA nephropathy (IgAN). High levels of urine ß2-microglobulin (ß2-MG) and retinol-binding protein (RBP) were observed in patients with IgAN with tubulointerstitial lesions. However, their roles in disease progression remain unclear. This study aimed to evaluate the associations of urine ß2-MG and RBP with the progression of IgAN.Methods:
We retrospectively investigated a cohort of 2,153 patients with IgAN. Clinical and pathological features, outcomes, and urine ß2-MG, and RBP at the time of biopsy were collected. The associations, of urine ß2-MG and RBP with the composite renal outcome, defined as a decline in estimated glomerular filtration rate (eGFR) of ≥50% from baseline or end-stage renal disease (ESRD), were examined using restricted cubic splines and the Cox proportional hazards models.Results:
During a median follow-up of 20.40 months, 140 (6.50%) patients reached the composite renal outcomes. Restricted cubic splines showed that patients with higher urinary ß2-MG and RBP levels had worse renal outcomes. The Cox regression analysis revealed that urine ß2-MG and RBP were associated with a risk of the composite renal outcome in the multivariate adjusted model [+1 SD for log ß2-MG, hazard ratio (HR) = 1.462, 95% CI 1.136-1.882, p = 0.003; +1 SD for log RBP, HR = 1.972, 95% CI 1.486-2.617, p = 0.001]. The associations were detectable within patients with baseline eGFR <90 ml/min/1.73 m2 (+1 SD for log ß2-MG, HR = 1.657, 95% CI 1.260-2.180, p < 0.001; +1 SD for log RBP, HR = 1.618, 95% CI 1.199-2.183, p = 0.002), but not among patients with eGFR ≥90 ml/min/1.73 m2.Conclusion:
Higher levels of urine ß2-MG and RBP were independent risk factors for renal disease progression in IgAN.
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Bases de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Front Med (Lausanne)
Año:
2021
Tipo del documento:
Article
País de afiliación:
China