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Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron.
Carreño, Juan Manuel; Alshammary, Hala; Tcheou, Johnstone; Singh, Gagandeep; Raskin, Ariel J; Kawabata, Hisaaki; Sominsky, Levy A; Clark, Jordan J; Adelsberg, Daniel C; Bielak, Dominika A; Gonzalez-Reiche, Ana Silvia; Dambrauskas, Nicholas; Vigdorovich, Vladimir; Srivastava, Komal; Sather, D Noah; Sordillo, Emilia Mia; Bajic, Goran; van Bakel, Harm; Simon, Viviana; Krammer, Florian.
Afiliación
  • Carreño JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Alshammary H; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Tcheou J; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Singh G; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Raskin AJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Kawabata H; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Sominsky LA; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Clark JJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Adelsberg DC; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Bielak DA; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Gonzalez-Reiche AS; Department of Genetics and Genomic Sciences, ISMMS, New York, NY, USA.
  • Dambrauskas N; Center for Global Infectious Disease Research, Seattle Children's Research Institute, University of Washington, Seattle, WA, USA.
  • Vigdorovich V; Center for Global Infectious Disease Research, Seattle Children's Research Institute, University of Washington, Seattle, WA, USA.
  • Srivastava K; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
  • Sather DN; Center for Global Infectious Disease Research, Seattle Children's Research Institute, University of Washington, Seattle, WA, USA.
  • Sordillo EM; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
  • Bajic G; Department of Pathology, Molecular and Cell-Based Medicine, ISMMS, New York, NY, USA. emilia.sordillo@mountsinai.org.
  • van Bakel H; Department of Microbiology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA. goran.bajic@mssm.edu.
  • Simon V; Department of Genetics and Genomic Sciences, ISMMS, New York, NY, USA. harm.vanbakel@mssm.edu.
  • Krammer F; Icahn Genomics Institute, ISMMS, New York, NY, USA. harm.vanbakel@mssm.edu.
Nature ; 602(7898): 682-688, 2022 02.
Article en En | MEDLINE | ID: mdl-35016197
The Omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially identified in November 2021 in South Africa and Botswana, as well as in a sample from a traveller from South Africa in Hong Kong1,2. Since then, Omicron has been detected globally. This variant appears to be at least as infectious as Delta (B.1.617.2), has already caused superspreader events3, and has outcompeted Delta within weeks in several countries and metropolitan areas. Omicron hosts an unprecedented number of mutations in its spike gene and early reports have provided evidence for extensive immune escape and reduced vaccine effectiveness2,4-6. Here we investigated the virus-neutralizing and spike protein-binding activity of sera from convalescent, double mRNA-vaccinated, mRNA-boosted, convalescent double-vaccinated and convalescent boosted individuals against wild-type, Beta (B.1.351) and Omicron SARS-CoV-2 isolates and spike proteins. Neutralizing activity of sera from convalescent and double-vaccinated participants was undetectable or very low against Omicron compared with the wild-type virus, whereas neutralizing activity of sera from individuals who had been exposed to spike three or four times through infection and vaccination was maintained, although at significantly reduced levels. Binding to the receptor-binding and N-terminal domains of the Omicron spike protein was reduced compared with binding to the wild type in convalescent unvaccinated individuals, but was mostly retained in vaccinated individuals.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Convalecencia / Anticuerpos Neutralizantes / Evasión Inmune / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Sueros Inmunes Límite: Adult / Female / Humans Idioma: En Revista: Nature Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Convalecencia / Anticuerpos Neutralizantes / Evasión Inmune / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Sueros Inmunes Límite: Adult / Female / Humans Idioma: En Revista: Nature Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos