Schisandrin B suppresses osteosarcoma lung metastasis <i>in vivo</i> by inhibiting the activation of the Wnt/ß­catenin and PI3K/Akt signaling pathways.

Wang, Yuping; Chen, Jin; Huang, Yanran; Yang, Shengdong; Tan, Tao; Wang, Nan; Zhang, Jun; Ye, Caihong; Wei, Mengqi; Luo, Jinyong; Luo, Xiaoji

Schisandrin B suppresses osteosarcoma lung metastasis in vivo by inhibiting the activation of the Wnt/ßcatenin and PI3K/Akt signaling pathways.

Wang, Yuping; Chen, Jin; Huang, Yanran; Yang, Shengdong; Tan, Tao; Wang, Nan; Zhang, Jun; Ye, Caihong; Wei, Mengqi; Luo, Jinyong; Luo, Xiaoji.

Afiliación

Wang Y; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Chen J; Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Huang Y; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Yang S; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Tan T; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Wang N; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Zhang J; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Ye C; Key Laboratory of Clinical Diagnosis of Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Wei M; Key Laboratory of Clinical Diagnosis of Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Luo J; Key Laboratory of Clinical Diagnosis of Education Ministry, College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Luo X; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.

Oncol Rep ; 47(3)2022 Mar.

Article en En | MEDLINE | ID: mdl-35029287

Asunto(s)

Lignanos/farmacología; Neoplasias Pulmonares/tratamiento farmacológico; Osteosarcoma/tratamiento farmacológico; Fosfatidilinositol 3-Quinasas/metabolismo; Compuestos Policíclicos/farmacología; Proteínas Proto-Oncogénicas c-akt/metabolismo; Vía de Señalización Wnt/efectos de los fármacos; beta Catenina/metabolismo; Animales; Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Neoplasias Óseas/tratamiento farmacológico; Neoplasias Óseas/patología; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Ciclooctanos/farmacología; Modelos Animales de Enfermedad; Humanos; Neoplasias Pulmonares/secundario; Ratones; Osteosarcoma/patología

Palabras clave

PI3K; Schisandrin B; Wnt/ßcatenin; lung metastasis; osteosarcoma

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Compuestos Policíclicos / Osteosarcoma / Lignanos / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / Beta Catenina / Vía de Señalización Wnt / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Oncol Rep Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article

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