Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss.
Ann N Y Acad Sci
; 1511(1): 133-141, 2022 05.
Article
en En
| MEDLINE
| ID: mdl-35029314
ABSTRACT
We compare the focal structure-function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (n = 46, mean ± SD age 67 ± 10 years; VF mean deviation -10.41 ± 6.76 dB) were included in this cross-sectional study. We performed 30-2 standard automated perimetry OCT (3.5-mm diameter ring scan) and 15°×15° OCT-A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT-A wedge and an OCT ring-sector. Two univariate linear models (Mv and Mt ) using either CD-based vascular (Mv ) or RNFL-T-based thickness information (Mt ) and one multivariate model using both (Mvt ) were compared in their associations with measured focal VFD, which were higher for the multivariate model Mvt (mean ± SD correlation coefficient 0.710 ± 0.086) than for either nested model (0.627 ± 0.078 for Mv and 0.578 ± 0.095 for Mt ). Using a focal visual field approach, the combination of RNFL-T and CD showed better structure-function correlations than thickness or vascular information only.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glaucoma de Ángulo Abierto
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Pruebas del Campo Visual
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Aged
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Humans
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Middle aged
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
2022
Tipo del documento:
Article
País de afiliación:
Austria