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Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers.
Colbert, Lauren E; El, Molly B; Lynn, Erica J; Bronk, Julianna; Karpinets, Tatiana V; Wu, Xiaogang; Chapman, Bhavana V; Sims, Travis T; Lin, Daniel; Kouzy, Ramez; Sammouri, Julie; Biegert, Greyson; Delgado Medrano, Andrea Y; Olvera, Adilene; Sastry, K Jagannadha; Eifel, Patricia J; Jhingran, Anuja; Lin, Lilie; Ramondetta, Lois M; Futreal, Andrew P; Jazaeri, Amir A; Schmeler, Kathleen M; Yue, Jingyan; Mitra, Aparna; Yoshida-Court, Kyoko; Wargo, Jennifer A; Solley, Travis N; Hegde, Venkatesh; Nookala, Sita S; Yanamandra, Ananta V; Dorta-Estremera, Stephanie; Mathew, Geena; Kavukuntla, Rohit; Papso, Cassidy; Ahmed-Kaddar, Mustapha; Kim, Minsoo; Zhang, Jianhua; Reuben, Alexandre; Holliday, Emma B; Minsky, Bruce D; Koong, Albert C; Koay, Eugene J; Das, Prajnan; Taniguchi, Cullen M; Klopp, Ann.
Afiliación
  • Colbert LE; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. lcolbert@mdanderson.org aklopp@mdanderson.org.
  • El MB; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Lynn EJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Bronk J; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Karpinets TV; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Wu X; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Chapman BV; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Sims TT; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Lin D; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Kouzy R; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Sammouri J; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Biegert G; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Delgado Medrano AY; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Olvera A; Department of Infectious Diseases and Infection Control, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Sastry KJ; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Eifel PJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Jhingran A; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Lin L; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Ramondetta LM; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Futreal AP; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Jazaeri AA; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Schmeler KM; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Yue J; McGovern Medical School at UTHealth, Houston, Texas.
  • Mitra A; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Yoshida-Court K; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Wargo JA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Solley TN; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Hegde V; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Nookala SS; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Yanamandra AV; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Dorta-Estremera S; McGovern Medical School at UTHealth, Houston, Texas.
  • Mathew G; Department of Microbiology and Medical Zoology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
  • Kavukuntla R; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Papso C; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Ahmed-Kaddar M; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Kim M; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Zhang J; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Reuben A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Holliday EB; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Minsky BD; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Koong AC; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Koay EJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Das P; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Taniguchi CM; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Klopp A; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Immunol Res ; 10(2): 259-271, 2022 02.
Article en En | MEDLINE | ID: mdl-35045973
ABSTRACT
Human papillomavirus (HPV) infection causes 600,000 new cancers worldwide each year. HPV-related cancers express the oncogenic proteins E6 and E7, which could serve as tumor-specific antigens. It is not known whether immunity to E6 and E7 evolves during chemoradiotherapy or affects survival. Using T cells from 2 HPV16+ patients, we conducted functional T-cell assays to identify candidate HPV-specific T cells and common T-cell receptor motifs, which we then analyzed across 86 patients with HPV-related cancers. The HPV-specific clones and E7-related T-cell receptor motifs expanded in the tumor microenvironment over the course of treatment, whereas non-HPV-specific T cells did not. In HPV16+ patients, improved recurrence-free survival was associated with HPV-responsive T-cell expansion during chemoradiotherapy.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Proteínas Oncogénicas Virales / Infecciones por Papillomavirus Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Cancer Immunol Res Año: 2022 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Proteínas Oncogénicas Virales / Infecciones por Papillomavirus Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Cancer Immunol Res Año: 2022 Tipo del documento: Article