Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii.
J Nat Prod
; 85(2): 384-390, 2022 02 25.
Article
en En
| MEDLINE
| ID: mdl-35057611
ABSTRACT
Diterpenoid pyrones are a type of mainly fungal meroterpenoid metabolite consisting of a diterpene connected to a pyrone, some of which show potent bioactivity. Through genome mining and heterologous expression, nine new diterpenoid pyrones, shearones A-I (1-9), were discovered from the fungus Eupenicillium shearii IFM 42152, and their biosynthetic enzyme activities were revealed. Some of these heterologously biosynthesized diterpenoid pyrones exhibited moderate antiaggregative ability against amyloid ß42 in vitro.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pironas
/
Diterpenos
Idioma:
En
Revista:
J Nat Prod
Año:
2022
Tipo del documento:
Article
País de afiliación:
Japón