Evaluation of stress myocardial blood flow patterns in patients with apical hypertrophic cardiomyopathy.
J Nucl Cardiol
; 29(4): 1946-1951, 2022 08.
Article
en En
| MEDLINE
| ID: mdl-35112308
ABSTRACT
BACKGROUND:
Among the other variants, the apical pattern of hypertrophic cardiomyopathy (AHCM) is probably the most important, with possible aneurysmatic evolution. METHODS ANDRESULTS:
We analyzed 12 patients with AHCM who underwent [13N]NH3-PET/CT. Regional perfusion, stress global myocardial blood flow (MBF), and transmural perfusion patterns were assessed. To evaluate the LV-MBF distribution, we compared the apex with septum and infero-lateral wall. Furthermore, global stress MBF distribution in AHCM patients was compared with a reference septal HCM cohort. Visual regional perfusion analysis demonstrated an apical hypoperfusion in 10 of 12 patients, without correlation with the stress MBF of the whole LV. Significant differences among stress MBF in apical, in septal, and in the infero-lateral walls were recorded (P < .02). The transmural analysis showed a significant difference among the three segment groups for epicardial (P < .003) as well for endocardial MBF (P < .005). In the post hoc analysis, the apical MBF was significantly lower than in septal and infero-lateral walls in epicardium (P < .005) and significantly lower than the infero-lateral MBF in endocardium (P < .001).CONCLUSION:
In patients with AHCM, more severe apical microvascular impairment was found as compared to patients with classical septal HCM, supporting the suspicion that ischemia could play a role in the future aneurysmatic evolution of AHCM.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Cardiomiopatía Hipertrófica
/
Imagen de Perfusión Miocárdica
Límite:
Humans
Idioma:
En
Revista:
J Nucl Cardiol
Asunto de la revista:
CARDIOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia