Provision of small-quantity lipid-based nutrient supplements does not improve intestinal health among rural Malawian children.
Matern Child Nutr
; 18(3): e13331, 2022 07.
Article
en En
| MEDLINE
| ID: mdl-35128820
Lipid-based nutrient supplements (LNS) have been found to improve child growth and reduce child mortality. However, the mechanistic pathways for these improvements warrant exploration. One potential pathway is linked to improvement in intestinal health. Our study aimed to test a hypothesis that small-quantity LNS (SQ-LNS) could reduce the levels of intestinal inflammation, repair and permeability of children. As intestinal health markers we measured fecal calprotectin, regenerating 1B protein (REG1B) and alpha-1-antitrypsin concentrations at 18 months of age (after 12 months of supplementation) and 1 year later (12 months after cessation of supplementation). In this analysis, we included data of 735 children who participated in a randomised dietary supplementation trial in rural Malawi; 243 children who received 20 g/day SQ-LNS from 6 to 18 months of age were in the SQ-LNS group, while the others who received no dietary supplementation during this period were in the control group. At 18 months of age, the mean concentrations of calprotectin, REG1B and alpha-1-antitrypsin were 241, 105 µg/g and 7.1 mg/dl, respectively, in the SQ-LNS group, and 224, 105 µg/g and 7.4 mg/dl, respectively, in the control group, and did not differ between the SQ-LNS and control groups. We conclude that SQ-LNS provision did not have an impact on children's intestinal health in rural Malawi.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Nutrientes
/
Suplementos Dietéticos
Tipo de estudio:
Clinical_trials
Límite:
Child
/
Humans
/
Infant
País/Región como asunto:
Africa
Idioma:
En
Revista:
Matern Child Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
PERINATOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Finlandia