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Cognitive screening in HTLV-1-infected people using a self-perceived memory score and auditory P300.
de Castro, Aline Rejane Rosa; Labanca, Ludimila; de Resende, Luciana Macedo; de Sousa, Marjore Rhaissa; Dias, Rafael Teixeira Scoralick; de Morais Caporali, Júlia Fonseca; Utsch-Gonçalves, Denise.
Afiliación
  • de Castro ARR; Graduate Program of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Labanca L; Graduate Program of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • de Resende LM; Graduate Program of Speech, Language, and Hearing Sciences, Faculty of Medicine, Universidade Federal de Minas Gerais, Av. Professor Alfredo Balena, 190, sala 199, Belo Horizonte, Minas Gerais, CEP 30110130, Brazil.
  • de Sousa MR; Graduate Program of Speech, Language, and Hearing Sciences, Faculty of Medicine, Universidade Federal de Minas Gerais, Av. Professor Alfredo Balena, 190, sala 199, Belo Horizonte, Minas Gerais, CEP 30110130, Brazil.
  • Dias RTS; Graduate Program of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • de Morais Caporali JF; Graduate Program of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Utsch-Gonçalves D; Graduate Program of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
J Neurovirol ; 28(1): 123-132, 2022 02.
Article en En | MEDLINE | ID: mdl-35167053
The HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the most common neurological manifestation associated with human T-cell lymphotropic virus type-1 (HTLV-1) infection. Although cognitive impairment has been highlighted in the spectrum of HTLV-1 neurological manifestations, it may go unnoticed in those who do not spontaneously report it. We aimed at evaluating the applicability of a self-perceived memory score (SMS) and the cognitive event-related potential (P300) for early detection of cognitive impairment in HTLV-1-infected people. The SMS was measured by a 0-10 point numeric scale combined with a sad-happy face rating scale. The higher the number, the better was the SMS. The P300 was obtained through an oddball paradigm with a mental counting task. The participants were 15 (21.4%) individuals with HAM/TSP, 20 (28.6%) HTLV-1 asymptomatic carriers, and 35 (50%) seronegative controls. We found that SMS (p < 0.001) and P300 latency (p < 0.001) got progressively worse from the seronegative controls to the asymptomatic carriers and then to the HAM/TSP. The results that indicated cognitive impairment were SMS < 7.2 points and P300 latency > 369.0 ms. The HAM/TSP group showed the highest prevalence of altered P300 (80%) and SMS (87%). Interestingly, the asymptomatic group also presented significantly higher prevalence of altered SMS (60%) and P300 (35%) when compared to controls (< 10%). The frequency of cognitive impairment was 16 times higher in the HTLV-1 asymptomatic group and 69 times higher in the HAM/TSP group when compared to controls. The use of SMS in the medical consultation was a useful and easy-to-apply method to screen HTLV-1-infected subjects for everyday memory complaints.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Virus Linfotrópico T Tipo 1 Humano / Infecciones por HTLV-I / Paraparesia Espástica Tropical / Disfunción Cognitiva Tipo de estudio: Diagnostic_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: J Neurovirol Asunto de la revista: NEUROLOGIA / VIROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Virus Linfotrópico T Tipo 1 Humano / Infecciones por HTLV-I / Paraparesia Espástica Tropical / Disfunción Cognitiva Tipo de estudio: Diagnostic_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: J Neurovirol Asunto de la revista: NEUROLOGIA / VIROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil