Respiratory and allergic outcomes among 5-year-old children exposed to pesticides.
Thorax
; 78(1): 41-49, 2023 01.
Article
en En
| MEDLINE
| ID: mdl-35210357
ABSTRACT
BACKGROUND:
Little is known about the effects of pesticides on children's respiratory and allergic outcomes. We evaluated associations of prenatal and current pesticide exposures with respiratory and allergic outcomes in children from the Infants' Environmental Health Study in Costa Rica.METHODS:
Among 5-year-old children (n=303), we measured prenatal and current specific gravity-corrected urinary metabolite concentrations of insecticides (chlorpyrifos, pyrethroids), fungicides (mancozeb, pyrimethanil, thiabendazole) and 2,4-D. We collected information from caregivers on respiratory (ever doctor-diagnosed asthma and lower respiratory tract infections (LRTI), wheeze and cough during last 12 months) and allergic (nasal allergies, itchy rash, ever eczema) outcomes. We fitted separate multivariable logistic regression models for high (≥75th percentile (P75)) vs low (CONCLUSIONS:
Current pyrethroid exposure may affect children's respiratory and allergic health at 5 years of age. Current mancozeb exposure might contribute to LRTI. These findings are important as pyrethroids are broadly used in home environments and agriculture and mancozeb in agriculture.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Plaguicidas
/
Piretrinas
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Infecciones del Sistema Respiratorio
/
Asma
/
Exantema
/
Rinitis Alérgica
Tipo de estudio:
Prognostic_studies
Límite:
Child, preschool
/
Female
/
Humans
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Infant
/
Pregnancy
Idioma:
En
Revista:
Thorax
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos