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Releasing the trap: How the segregase p97 extracts PARP1 from chromatin.
Götz, Maximilian J; Stingele, Julian.
Afiliación
  • Götz MJ; Department of Biochemistry, Ludwig-Maximilians-University, 81377 Munich, Germany; Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany.
  • Stingele J; Department of Biochemistry, Ludwig-Maximilians-University, 81377 Munich, Germany; Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany. Electronic address: stingele@genzentrum.lmu.de.
Mol Cell ; 82(5): 889-890, 2022 03 03.
Article en En | MEDLINE | ID: mdl-35245455
Krastev et al. (2022) identify a cellular mechanism that counteracts cytotoxic trapping of PARP1 induced by clinical PARP inhibitors. SUMO-targeted ubiquitylation of trapped PARP1 is shown to trigger the enzymes' extraction from chromatin by the p97 ATPase.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cromatina / Inhibidores de Poli(ADP-Ribosa) Polimerasas Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cromatina / Inhibidores de Poli(ADP-Ribosa) Polimerasas Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Alemania