Losartan treatment attenuates hindlimb unloading-induced atrophy in the soleus muscle of female rats via canonical TGF-ß signaling.
J Physiol Sci
; 72(1): 6, 2022 Mar 09.
Article
en En
| MEDLINE
| ID: mdl-35264097
ABSTRACT
We investigated the protective effect of losartan, an angiotensin II type 1 receptor blocker, on soleus muscle atrophy. Age-matched male and female Wistar rats were subjected to hindlimb unloading, and the soleus muscle was removed on days 1 and 7 for analysis. Females showed greater reductions in relative weight and myofiber cross-sectional area of the soleus muscle than males on day 7 post-hindlimb unloading. Losartan partially protected females against muscle atrophy. Activation of the canonical TGF-ß signaling pathway, assessed via Smad2/3 phosphorylation, was lower in females following losartan treatment and associated with lower levels of protein ubiquitination after 1 (myofibril) and 7 (cytosol) days of unloading. However, no effect was observed in non-canonical TGF-ß signaling (p44/p42 and p38 MAPK phosphorylation) in males or females during unloading. Our results suggest that losartan provides partial protection against hindlimb unloading-induced soleus muscle atrophy in female rats, possibly associated with decreased canonical TGF-ß signaling.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Suspensión Trasera
/
Losartán
Límite:
Animals
Idioma:
En
Revista:
J Physiol Sci
Asunto de la revista:
FISIOLOGIA
/
TRAUMATOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Japón