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Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides.
Khirsariya, Prashant; Pospísil, Patrik; Maier, Lukás; Boudný, Miroslav; Babás, Martin; Kroutil, Ondrej; Mráz, Marek; Vácha, Robert; Paruch, Kamil.
Afiliación
  • Khirsariya P; Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
  • Pospísil P; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, 602 00 Brno, Czech Republic.
  • Maier L; Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
  • Boudný M; Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
  • Babás M; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, 602 00 Brno, Czech Republic.
  • Kroutil O; Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
  • Mráz M; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavska 20, 625 00 Brno, Czech Republic.
  • Vácha R; Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
  • Paruch K; Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
J Med Chem ; 65(7): 5701-5723, 2022 04 14.
Article en En | MEDLINE | ID: mdl-35302777
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Metiltransferasas / Nucleósidos Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: República Checa
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Metiltransferasas / Nucleósidos Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: República Checa