A local QSAR model based on the stability of nitrenium ions to support the ICH M7 expert review on the mutagenicity of primary aromatic amines.

Furukawa, Ayaka; Ono, Satoshi; Yamada, Katsuya; Torimoto, Nao; Asayama, Mahoko; Muto, Shigeharu

Furukawa, Ayaka; Ono, Satoshi; Yamada, Katsuya; Torimoto, Nao; Asayama, Mahoko; Muto, Shigeharu.

Afiliación

Furukawa A; Safety Research Laboratories, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan. furukawa.ayaka@ma.mt-pharma.co.jp.
Ono S; Discovery Technology Laboratories, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa, 227-0033, Japan. ono.satoshi@mg.mt-pharma.co.jp.
Yamada K; Safety Research Laboratories, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan.
Torimoto N; Discovery Technology Laboratories, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa, 227-0033, Japan.
Asayama M; Safety Research Laboratories, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan.
Muto S; Safety Research Laboratories, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan.

Genes Environ ; 44(1): 10, 2022 Mar 21.

Article en En | MEDLINE | ID: mdl-35313995

Palabras clave

Expert review; ICH M7; In silico; Nitrenium ion; Primary aromatic amine; Quantitative structureactivity relationship (QSAR)

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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Genes Environ Año: 2022 Tipo del documento: Article País de afiliación: Japón

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