Quality control of protein complex composition.
Mol Cell
; 82(8): 1439-1450, 2022 04 21.
Article
en En
| MEDLINE
| ID: mdl-35316660
ABSTRACT
Eukaryotic cells possess hundreds of protein complexes that contain multiple subunits and must be formed at the correct time and place during development. Despite specific assembly pathways, cells frequently encounter complexes with missing or aberrant subunits that can disrupt important signaling events. Cells, therefore, employ several ubiquitin-dependent quality control pathways that can prevent, correct, or degrade flawed complexes. In this review, we will discuss our emerging understanding of such quality control of protein complex composition.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ubiquitina
/
Complejo de la Endopetidasa Proteasomal
Idioma:
En
Revista:
Mol Cell
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos