Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives.
Amino Acids
; 54(7): 1101-1108, 2022 Jul.
Article
en En
| MEDLINE
| ID: mdl-35377022
ABSTRACT
The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of L-arginine and some of its derivatives. This study investigated the effect of 113 chemically diverse and commonly used drugs (at 20 and 200 µM) on the CAT1-mediated cellular uptake of L-arginine, L-homoarginine, and asymmetric dimethylarginine (ADMA). Twenty-three (20%) of the tested substances showed weak inhibitory or stimulatory effects, but only verapamil showed consistent inhibitory effects on CAT1-mediated transport of all tested substrates.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Arginina
/
Transportador de Aminoácidos Catiónicos 1
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Amino Acids
Asunto de la revista:
BIOQUIMICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Alemania