Z-&#945;<sub>1</sub>-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state.

Chambers, Joseph E; Zubkov, Nikita; Kubánková, Markéta; Nixon-Abell, Jonathon; Mela, Ioanna; Abreu, Susana; Schwiening, Max; Lavarda, Giulia; López-Duarte, Ismael; Dickens, Jennifer A; Torres, Tomás; Kaminski, Clemens F; Holt, Liam J; Avezov, Edward; Huntington, James A; George-Hyslop, Peter St; Kuimova, Marina K; Marciniak, Stefan J

Z-α₁-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state.

Chambers, Joseph E; Zubkov, Nikita; Kubánková, Markéta; Nixon-Abell, Jonathon; Mela, Ioanna; Abreu, Susana; Schwiening, Max; Lavarda, Giulia; López-Duarte, Ismael; Dickens, Jennifer A; Torres, Tomás; Kaminski, Clemens F; Holt, Liam J; Avezov, Edward; Huntington, James A; George-Hyslop, Peter St; Kuimova, Marina K; Marciniak, Stefan J.

Afiliación

Chambers JE; Cambridge Institute for Medical Research (CIMR), Department of Medicine, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.
Zubkov N; Cambridge Institute for Medical Research (CIMR), Department of Medicine, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.
Kubánková M; Department of Chemistry, Imperial College London, Wood Lane, London W12 0BZ, UK.
Nixon-Abell J; Cambridge Institute for Medical Research (CIMR), Department of Medicine, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.
Mela I; Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.
Abreu S; Cambridge Institute for Medical Research (CIMR), Department of Medicine, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.
Schwiening M; Cambridge Institute for Medical Research (CIMR), Department of Medicine, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.
Lavarda G; Departamento de Química Orgánica and Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, Madrid 28049, Spain.
López-Duarte I; Departamento de Química Orgánica and Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, Madrid 28049, Spain.
Dickens JA; Cambridge Institute for Medical Research (CIMR), Department of Medicine, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.
Torres T; Departamento de Química Orgánica and Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, Madrid 28049, Spain.
Kaminski CF; IMDEA Nanociencia, Campus de Cantoblanco, Madrid 28049, Spain.
Holt LJ; Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.
Avezov E; Institute for Systems Genetics, New York University Grossman School of Medicine, 435 E 30th St, New York, NY 10016, USA.
Huntington JA; Department of Clinical Neurosciences and UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK.
George-Hyslop PS; Cambridge Institute for Medical Research (CIMR), Department of Medicine, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.
Kuimova MK; Cambridge Institute for Medical Research (CIMR), Department of Medicine, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.
Marciniak SJ; Department of Medicine (Neurology), Temerty Faculty of Medicine, University of Toronto, University Health Network, Toronto, ON M5T 0S8, Canada.

Sci Adv ; 8(14): eabm2094, 2022 Apr 08.

Article en En | MEDLINE | ID: mdl-35394846

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido