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Real-world experience of anti-D immunoglobulin in immune thrombocytopenia.
Mishra, Kundan; Kumar, Suman; Singh, Kanwaljeet; Jandial, Aditya; Sandal, Rajeev; Sahu, Kamal Kant; Khera, Sanjeev; Kumar, Rajiv; Kapoor, Rajan; Sharma, Sanjeevan; Singh, Jasjit; Das, Satyaranjan; Chatterjee, Tathagat; Sharma, Ajay; Nair, Velu.
Afiliación
  • Mishra K; Department of Clinical Hematology and Stem Cell Transplant, Army Hospital (Research & Referral), Delhi, 110010, India.
  • Kumar S; Department of Clinical Hematology and Stem Cell Transplant, Army Hospital (Research & Referral), Delhi, 110010, India. hematologyhod@gmail.com.
  • Singh K; Depatment of Lab Sciences and Molecular Medicine, Army Hospital (Research & Referral), Delhi, India.
  • Jandial A; Department of Internal Medicine, PGIMER, Chandigarh, India.
  • Sandal R; Department of Radiotherapy and Oncology, IGMC Shimla, Himachal Pradesh, India.
  • Sahu KK; Division of Hematology and Medical Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.
  • Khera S; Department of Pediatrics, Army Hospital (Research & Referral), Delhi, India.
  • Kumar R; Department of Clinical Hematology and Stem Cell Transplant, Army Hospital (Research & Referral), Delhi, 110010, India.
  • Kapoor R; Department of Internal Medicine, INHS Asvini, Mumbai, India.
  • Sharma S; Department of Clinical Hematology and Stem Cell Transplant, Army Hospital (Research & Referral), Delhi, 110010, India.
  • Singh J; Department of Internal Medicine, Command Hospital (Eastern Command), Kolkata, India.
  • Das S; Department of Clinical Hematology and Stem Cell Transplant, Army Hospital (Research & Referral), Delhi, 110010, India.
  • Chatterjee T; Department of Internal Medicine, Command Hospital (Central Command), Lucknow, India.
  • Sharma A; Department of Clinical Hematology and Stem Cell Transplant, Army Hospital (Research & Referral), Delhi, 110010, India.
  • Nair V; Department of Internal Medicine, Command Hospital (Western Command), Chandimandir, India.
Ann Hematol ; 101(6): 1173-1179, 2022 Jun.
Article en En | MEDLINE | ID: mdl-35396605
In developing countries, anti-D has been used in immune thrombocytopenia (ITP) as a cheaper alternative to human immunoglobulin. We aim to analyze the response and safety profile of anti-D in patients with severe ITP. A retrospective study was conducted at a tertiary care hospital in Northern India. Patients received a single intravenous infusion of 75 µg/kg anti-D. In total, 36 patients (20 females) were included in this study. The median duration from ITP diagnosis to anti-D therapy was 235 days (range 1-1613 days). Four (11.1%) patients received anti-D as an upfront treatment. The patients' platelet counts rose significantly by the end of day three and continued to be significantly high until day 30 of receiving anti-D (p ≤ 0.001). The overall response rate (ORR) by day seven was 88.89%. There was no effect of age, sex, duration of disease, prior therapy, and platelet count on the ORR. Patients were followed up for a median duration of 52 days (longest follow-up: 3080 days). Six (6/36, 16.67%) patients continued to be in remission till the last follow-up. The hemoglobin fall was statistically significant on day three and day seven (p < 0.001 and p = 0.001) and got normalized by day 30. We observed equally good ORR in mixed populations and different phases of ITP along with long-term sustained response. The study demonstrates a quick and high response rate along with good safety profile to anti-D in all forms of ITP.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trombocitopenia / Púrpura Trombocitopénica Idiopática Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Female / Humans / Male Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trombocitopenia / Púrpura Trombocitopénica Idiopática Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Female / Humans / Male Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: India