PM2.5 composition and disease aggravation in amyotrophic lateral sclerosis: An analysis of long-term exposure to components of fine particulate matter in New York State.
Environ Epidemiol
; 6(2): e204, 2022 Apr.
Article
en En
| MEDLINE
| ID: mdl-35434459
ABSTRACT
Long-term exposure to fine particulate matter (PM2.5) has been associated with disease aggravation in amyotrophic lateral sclerosis (ALS). In this study, we characterized long-term exposure to six major PM2.5 components and their individual association with disease aggravation in ALS. Methods:
We leveraged 15 years of data from the New York Department of Health Statewide Planning and Research Cooperative System (2000-2014) to calculate annual ALS first hospitalizations in New York State. We used the first hospital admission as a surrogate of disease aggravation and a prediction model to estimate population-weighted annual black carbon, organic matter (OM), nitrate, sulfate, sea salt, and soil concentrations at the county level. We used a multi-pollutant mixed quasi-Poisson model with county-specific random intercepts to estimate rate ratios (RR) of 1-year exposure to each PM2.5 component and disease aggravation in ALS, adjusting for potential confounders.Results:
We observed 5,655 first ALS-related hospitalizations. The annual average hospitalization count per county was 6.08 and the average PM2.5 total mass concentration per county was 8.1 µg/m3-below the United States' National Ambient Air Quality Standard of 12 µg/m3. We found a consistent positive association between ALS aggravation and OM (1.17, 95% confidence intervals [CI], 1.11, 1.24 per standard deviation [SD] increase) and a negative association with soil (RR = 0.91, 95% CI, 0.86, 0.97).Conclusion:
Our findings suggest that PM2.5 composition may influence its effect on ALS. We found that annual increases in county-level particulate OM may be associated with disease aggravation in ALS, even at PM2.5 levels below current standards.
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Bases de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Environ Epidemiol
Año:
2022
Tipo del documento:
Article