A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape.

Kellner, Markus; von Neubeck, Bettina; Czogalla, Bastian; Feederle, Regina; Vick, Binje; Jeremias, Irmela; Zeidler, Reinhard

Kellner, Markus; von Neubeck, Bettina; Czogalla, Bastian; Feederle, Regina; Vick, Binje; Jeremias, Irmela; Zeidler, Reinhard.

Afiliación

Kellner M; Research Group Therapeutic Antibodies, Helmholtz Zentrum München German Research Center for Environmental Health, Feodor-Lynen-Str. 21, 81377 Munich, Germany.
von Neubeck B; Research Group Therapeutic Antibodies, Helmholtz Zentrum München German Research Center for Environmental Health, Feodor-Lynen-Str. 21, 81377 Munich, Germany.
Czogalla B; Department of Obstetrics and Gynecology, University Hospital, Ludwig Maximilian Universität, 81377 Munich, Germany.
Feederle R; Core Facility Monoclonal Antibodies, Helmholtz Zentrum München German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
Vick B; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München German Research Center for Environmental Health, Feodor-Lynen-Str. 21, 81377 Munich, Germany.
Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München German Research Center for Environmental Health, Feodor-Lynen-Str. 21, 81377 Munich, Germany.
Zeidler R; Department of Pediatrics, University Hospital, Ludwig Maximilian Universität, 80337 Munich, Germany.

Biomedicines ; 10(4)2022 Mar 31.

Article en En | MEDLINE | ID: mdl-35453575

Palabras clave

CD73; adenosine; cancer therapy; extracellular vesicles; immune evasion; therapeutic antibody

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Alemania