Switchable, Reagent-Controlled C(sp<sup>3</sup>)-H Selective Iodination and Acetoxylation of 8-Methylquinolines.

Zhang, Ming-Lu; Zhang, Xing-Long; Guo, Rui-Li; Wang, Meng-Yue; Zhao, Bao-Yin; Yang, Jin-Hui; Jia, Qiong; Wang, Yong-Qiang

Switchable, Reagent-Controlled C(sp³)-H Selective Iodination and Acetoxylation of 8-Methylquinolines.

Zhang, Ming-Lu; Zhang, Xing-Long; Guo, Rui-Li; Wang, Meng-Yue; Zhao, Bao-Yin; Yang, Jin-Hui; Jia, Qiong; Wang, Yong-Qiang.

Afiliación

Zhang ML; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, School of Foreign Languages, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China.
Zhang XL; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, School of Foreign Languages, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China.
Guo RL; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, School of Foreign Languages, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China.
Wang MY; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, School of Foreign Languages, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China.
Zhao BY; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, School of Foreign Languages, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China.
Yang JH; State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, Yinchuan 750021, P. R. China.
Jia Q; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, School of Foreign Languages, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China.
Wang YQ; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, School of Foreign Languages, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China.

J Org Chem ; 87(9): 5730-5743, 2022 May 06.

Article en En | MEDLINE | ID: mdl-35471034

ABSTRACT

ABSTRACT

An efficient Pd-catalyzed C(sp3)-H selective iodination of 8-methylquinolines is reported herein for the first time. Because of the versatility of organic iodides, the method offers a facile access to various C8-substituted quinolines. By slightly switching the reaction conditions, an efficient C(sp3)-H acetoxylation of 8-methylquinolines has also been enabled. Both approaches feature mild reaction conditions, good tolerance of functional groups, and a broad substrate scope.

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2022 Tipo del documento: Article