A 'NAC' for targeting proteins to the ER.
Trends Biochem Sci
; 47(9): 730-731, 2022 09.
Article
en En
| MEDLINE
| ID: mdl-35501234
ABSTRACT
The signal recognition particle (SRP) cotranslationally targets a large and diverse portion of the nascent proteome to the endoplasmic reticulum (ER). A recent study by Jomaa et al. reveals an unexpected function for the ribosome-bound nascent chain-associated complex (NAC) in sensing ER-targeting signals and recruiting SRP to the appropriate ribosomes for high-fidelity targeting.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Partícula de Reconocimiento de Señal
/
Retículo Endoplásmico
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos