The pharmacokinetics of tacrolimus in peripheral blood mononuclear cells and limited sampling strategy for estimation of exposure in renal transplant recipients.

Wang, Xi-Han; Shao, Kun; An, Hui-Min; Zhai, Xiao-Hui; Zhou, Pei-Jun; Chen, Bing

Wang, Xi-Han; Shao, Kun; An, Hui-Min; Zhai, Xiao-Hui; Zhou, Pei-Jun; Chen, Bing.

Afiliación

Wang XH; Department of Pharmacy, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Shao K; Center for Organ Transplantation, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, People's Republic of China.
An HM; Center for Organ Transplantation, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, People's Republic of China.
Zhai XH; Department of Pharmacy, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Zhou PJ; Center for Organ Transplantation, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, People's Republic of China. peijunzhou@yahoo.com.
Chen B; Department of Pharmacy, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. chchenbing@hotmail.com.

Eur J Clin Pharmacol ; 78(8): 1261-1272, 2022 Aug.

Article en En | MEDLINE | ID: mdl-35536394

Asunto(s)

Citocromo P-450 CYP3A; Inmunosupresores; Trasplante de Riñón; Tacrolimus; Subfamilia B de Transportador de Casetes de Unión a ATP/genética; Área Bajo la Curva; Teorema de Bayes; Citocromo P-450 CYP3A/genética; Humanos; Inmunosupresores/administración & dosificación; Inmunosupresores/farmacocinética; Leucocitos Mononucleares; Tacrolimus/administración & dosificación; Tacrolimus/farmacocinética; Receptores de Trasplantes

Palabras clave

Area under the concentrationtime curve (AUC); Limited sampling strategy (LSS); Peripheral blood mononuclear cells (PBMC); Pharmacokinetics; Tacrolimus (TAC)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trasplante de Riñón / Tacrolimus / Citocromo P-450 CYP3A / Inmunosupresores Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Clin Pharmacol Año: 2022 Tipo del documento: Article

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