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Mitochondrial metabolism mediated macrophage polarization in chronic lung diseases.
Dong, Ting; Chen, Xinyi; Xu, Haochuan; Song, Yaxin; Wang, Huirui; Gao, Yinghui; Wang, Jingcheng; Du, Ruiqing; Lou, Hongxiang; Dong, Ting.
Afiliación
  • Dong T; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University; 44 Wenhuaxi Road, Jinan, Shandong, China.
  • Chen X; Institute of Infection and Transplantation, University College London; The Pears Building, Pond Street, London, NW3 2PP, UK.
  • Xu H; Peking University Health Sciences Center; No.38 Xueyuan Road, Haidian District, Beijing, China.
  • Song Y; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University; 44 Wenhuaxi Road, Jinan, Shandong, China.
  • Wang H; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University; 44 Wenhuaxi Road, Jinan, Shandong, China.
  • Gao Y; Department of Pharmacy, Shandong University of Traditional Chinese Medicine; 44 Wenhuaxi Road, Jinan, Shandong, China.
  • Wang J; Department of Pharmacy, Shandong University of Traditional Chinese Medicine; 44 Wenhuaxi Road, Jinan, Shandong, China.
  • Du R; Department of Pharmacy, Shandong University of Traditional Chinese Medicine; 44 Wenhuaxi Road, Jinan, Shandong, China.
  • Lou H; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University; 44 Wenhuaxi Road, Jinan, Shandong, China. Electronic address: louhongxiang@sdu.edu.cn.
  • Dong T; Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University; 44 Wenhuaxi Road, Jinan, Shandong, China. Electronic address: tingdong2021@sdu.edu.cn.
Pharmacol Ther ; 239: 108208, 2022 11.
Article en En | MEDLINE | ID: mdl-35569553
ABSTRACT
As the first line of defence in the lung, alveolar macrophage contributes to maintaining lung immune homoeostasis. Characterized by the heterogeneity and plasticity, macrophages polarize into two pro-inflammatory and anti-inflammatory phenotypes regarding the biological and pathological environment. In the past decade, numerous studies have revolutionized the relationship between cellular metabolism and macrophage functions. Mitochondria dysfunctions, which results in altered cellular metabolic profile, were observed in the alveolar macrophages during chronic lung diseases. In addition, alveolar macrophages adapt metabolic reprogramming to produce an immune response against the pathogens. Here, we outline the role of mitochondria in the development of macrophage phenotypes and functions and highlight the mitochondrial dysfunction in the setting of chronic lung diseases. Lastly, we emphasize the therapeutic relevance of targeting metabolic pathways in alveolar macrophages, which may shed light on developing novel strategies against chronic lung diseases.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades Pulmonares / Macrófagos Límite: Humans Idioma: En Revista: Pharmacol Ther Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades Pulmonares / Macrófagos Límite: Humans Idioma: En Revista: Pharmacol Ther Año: 2022 Tipo del documento: Article País de afiliación: China