The ERG1 K+ Channel and Its Role in Neuronal Health and Disease.
Front Mol Neurosci
; 15: 890368, 2022.
Article
en En
| MEDLINE
| ID: mdl-35600076
ABSTRACT
The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1's relationship to the mammalian brain and highlights key questions that have yet to be answered.
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MEDLINE
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En
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Front Mol Neurosci
Año:
2022
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Article
País de afiliación:
Estados Unidos