Probiotics Function in Preventing Atopic Dermatitis in Children.
Int J Mol Sci
; 23(10)2022 May 12.
Article
en En
| MEDLINE
| ID: mdl-35628229
ABSTRACT
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by relapsing eczematous injuries and severe pruritus. In the last few years, the AD prevalence has been increasing, reaching 20% in children and 10% in adults in high-income countries. Recently, the potential role of probiotics in AD prevention has generated considerable interest. As many clinical studies show, the gut microbiota is able to modulate systemic inflammatory and immune responses influencing the development of sensitization and allergy. Probiotics are used increasingly against AD. However, the molecular mechanisms underlying the probiotics mediated anti-allergic effect remain unclear and there is controversy about their efficacy. In this narrative review, we examine the actual evidence on the effect of probiotic supplementation for AD prevention in the pediatric population, discussing also the potential biological mechanisms of action in this regard.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Probióticos
/
Dermatitis Atópica
/
Microbioma Gastrointestinal
/
Hipersensibilidad
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Child
/
Humans
Idioma:
En
Revista:
Int J Mol Sci
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia