Low-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of ß- and γ-Relaxation in Pharmaceutical Glasses.
Anal Chem
; 94(23): 8241-8248, 2022 06 14.
Article
en En
| MEDLINE
| ID: mdl-35647784
ABSTRACT
In an earlier investigation, low-frequency Raman (LFR) spectroscopy was shown to detect the transition temperature of the ß-relaxation (Tß) in both amorphous celecoxib and various celecoxib amorphous solid dispersions [BeÌ
rzins, K. Mol. Pharmaceutics 2021, 18(10), 3882-3893]. In this study, we further investigated the application of this technique to determine Tß, an important parameter for estimating crystallization potency of amorphous drugs. Alongside commercially available amorphous drugs (zafirlukast and valsartan disodium salt), differently melt-quenched samples of cimetidine were also analyzed. Overall, the variable-temperature LFR measurements allowed for an easy access to the desired information, including the even lesser transition of the tertiary relaxation motions (Tγ). Thus, the obtained results not only highlighted the sensitivity, but also the practical usefulness of this technique to elucidate (subtle) changes in molecular dynamics within amorphous pharmaceutical systems.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Espectrometría Raman
/
Celecoxib
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Anal Chem
Año:
2022
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda