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Vitamin D as a Risk Factor for Multiple Sclerosis: Immunoregulatory or Neuroprotective?
Gombash, Sara E; Lee, Priscilla W; Sawdai, Elizabeth; Lovett-Racke, Amy E.
Afiliación
  • Gombash SE; Department of Neuroscience, The Ohio State University, Columbus, OH, United States.
  • Lee PW; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
  • Sawdai E; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
  • Lovett-Racke AE; Department of Neuroscience, The Ohio State University, Columbus, OH, United States.
Front Neurol ; 13: 796933, 2022.
Article en En | MEDLINE | ID: mdl-35651353
Vitamin D insufficiency during childhood has been linked to the development of multiple sclerosis (MS), typically an adult-onset inflammatory demyelinating disease of the central nervous system (CNS). Since vitamin D was known to have immunoregulatory properties on both innate and adaptive immunity, it was hypothesized that low vitamin D resulted in aberrant immune responses and the development of MS. However, vitamin D receptors are present on many cell types, including neurons, oligodendrocytes, astrocytes and microglia, and vitamin D has profound effects on development and function of the CNS. This leads to the possibility that low vitamin D may alter the CNS in a manner that makes it vulnerable to inflammation and the development of MS. This review analysis the role of vitamin D in the immune and nervous system, and how vitamin D insufficiency in children may contribute to the development of MS.
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies Idioma: En Revista: Front Neurol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies Idioma: En Revista: Front Neurol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos