Active conductive head cooling of normal and infarcted brain: A magnetic resonance spectroscopy imaging study.
J Cereb Blood Flow Metab
; 42(11): 2058-2065, 2022 11.
Article
en En
| MEDLINE
| ID: mdl-35707879
ABSTRACT
Active conductive head cooling is a simple and non-invasive intervention that may slow infarct growth in ischemic stroke. We investigated the effect of active conductive head cooling on brain temperature using whole brain echo-planar spectroscopic imaging. A cooling cap (WElkins Temperature Regulation System, 2nd Gen) was used to administer cooling for 80 minutes to healthy volunteers and chronic stroke patients. Whole brain echo-planar spectroscopic imaging scans were obtained before and after cooling. Brain temperature was estimated using the Metabolite Imaging and Data Analysis System software package, which allows voxel-level temperature calculations using the chemical shift difference between metabolite (N-acetylaspartate, creatine, choline) and water resonances. Eleven participants (six healthy volunteers, five post-stroke) underwent 80 ± 5 minutes of cooling. The average temperature of the coolant was 1.3 ± 0.5°C below zero. Significant reductions in brain temperature (ΔT = -0.9 ± 0.7°C, P = 0.002), and to a lesser extent, rectal temperature (ΔT = -0.3 ± 0.1°C, P = 0.03) were observed. Exploratory analysis showed that the occipital lobes had the greatest reduction in temperature (ΔT = -1.5 ± 1.2°C, P = 0.002). Regions of infarction had similar temperature reductions to the contralateral normal brain. Future research could investigate the feasibility of head cooling as a potential neuroprotective strategy in patients being considered for acute stroke therapies.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Accidente Cerebrovascular
/
Hipotermia Inducida
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Año:
2022
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda