Dramatic Recovery after Etoposide Phosphate Infusion for Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome following Treatment with Tisagenlecleucel in a Young Patient with Relapsed Acute Lymphoblastic Leukemia: A Case Report.
Acta Haematol
; 145(5): 537-541, 2022.
Article
en En
| MEDLINE
| ID: mdl-35724631
ABSTRACT
The occurrence of a secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) after CAR T-cell infusion is very rare and mostly fatal. Treatment recommendations for such a complication are not yet established. Here, we report the dramatic recovery of HLH/MAS following tisagenlecleucel infusion in a young patient with relapsed acute lymphoblastic leukemia using etoposide phosphate (EP). We propose that monitoring for the occurrence of HLH/MAS should be part of surveillance after CAR T-cell infusion and that EP treatment appears to be useful to control this severe and rare complication.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Linfohistiocitosis Hemofagocítica
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Síndrome de Activación Macrofágica
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Guideline
Límite:
Humans
Idioma:
En
Revista:
Acta Haematol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Francia