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Development of Two Mouse Models for Vaccine Evaluation against Cryptosporidiosis.
Dayao, Denise Ann; Jaskiewcz, Justyna; Lee, Sangun; Oliveira, Bruno Cesar; Sheoran, Abhineet; Widmer, Giovanni; Tzipori, Saul.
Afiliación
  • Dayao DA; Department of Infectious Disease and Global Health; Cummings School of Veterinary Medicine, Tufts Universitygrid.429997.8, North Grafton, Massachusetts, USA.
  • Jaskiewcz J; Department of Infectious Disease and Global Health; Cummings School of Veterinary Medicine, Tufts Universitygrid.429997.8, North Grafton, Massachusetts, USA.
  • Lee S; Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospitalgrid.32224.35, Harvard Medical School, and Shriners Hospitals for Children, Boston, Massachusetts, USA.
  • Oliveira BC; Department of Infectious Disease and Global Health; Cummings School of Veterinary Medicine, Tufts Universitygrid.429997.8, North Grafton, Massachusetts, USA.
  • Sheoran A; Department of Infectious Disease and Global Health; Cummings School of Veterinary Medicine, Tufts Universitygrid.429997.8, North Grafton, Massachusetts, USA.
  • Widmer G; União das Faculdades dos Grandes Lagos, São José do Rio Preto, Brazil.
  • Tzipori S; Department of Infectious Disease and Global Health; Cummings School of Veterinary Medicine, Tufts Universitygrid.429997.8, North Grafton, Massachusetts, USA.
Infect Immun ; 90(7): e0012722, 2022 07 21.
Article en En | MEDLINE | ID: mdl-35735982
Cryptosporidiosis was shown a decade ago to be a major contributor to morbidity and mortality of diarrheal disease in children in low-income countries. A serious obstacle to develop and evaluate immunogens and vaccines to control this disease is the lack of well-characterized immunocompetent rodent models. Here, we optimized and compared two mouse models for the evaluation of vaccines: the Cryptosporidium tyzzeri model, which is convenient for screening large numbers of potential mixtures of immunogens, and the Cryptosporidium parvum-infected mouse pretreated with interferon gamma-neutralizing monoclonal antibody.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cryptosporidium parvum / Criptosporidiosis / Cryptosporidium Límite: Animals Idioma: En Revista: Infect Immun Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cryptosporidium parvum / Criptosporidiosis / Cryptosporidium Límite: Animals Idioma: En Revista: Infect Immun Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos