Branching out: redox strategies towards the synthesis of acyclic α-tertiary ethers.
Chem Soc Rev
; 51(14): 5878-5929, 2022 Jul 18.
Article
en En
| MEDLINE
| ID: mdl-35770619
ABSTRACT
Acyclic α-tertiary ethers represent a highly prevalent functionality, common to high-value bioactive molecules, such as pharmaceuticals and natural products, and feature as crucial synthetic handles in their construction. As such their synthesis has become an ever-more important goal in synthetic chemistry as the drawbacks of traditional strong base- and acid-mediated etherifications have become more limiting. In recent years, the generation of highly reactive intermediates via redox approaches has facilitated the synthesis of highly sterically-encumbered ethers and accordingly these strategies have been widely applied in α-tertiary ether synthesis. This review summarises and appraises the state-of-the-art in the application of redox strategies enabling acyclic α-tertiary ether synthesis.
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1
Bases de datos:
MEDLINE
Asunto principal:
Productos Biológicos
/
Éteres
Idioma:
En
Revista:
Chem Soc Rev
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido