Lanthanide porphyrinoids as molecular theranostics.
Chem Soc Rev
; 51(14): 6177-6209, 2022 Jul 18.
Article
en En
| MEDLINE
| ID: mdl-35792133
ABSTRACT
In recent years, lanthanide (Ln) porphyrinoids have received increasing attention as theranostics. Broadly speaking, the term 'theranostics' refers to agents designed to allow both disease diagnosis and therapeutic intervention. This Review summarises the history and the 'state-of-the-art' development of Ln porphyrinoids as theranostic agents. The emphasis is on the progress made within the past decade. Applications of Ln porphyrinoids in near-infrared (NIR, 650-1700 nm) fluorescence imaging (FL), magnetic resonance imaging (MRI), radiotherapy, and chemotherapy will be discussed. The use of Ln porphyrinoids as photo-activated agents ('phototheranostics') will also be highlighted in the context of three promising strategies for regulation of porphyrinic triplet energy dissipation pathways, namely regioisomeric effects, metal regulation, and the use of expanded porphyrinoids. The goal of this Review is to showcase some of the ongoing efforts being made to optimise Ln porphyrinoids as theranostics and as phototheranostics, in order to provide a platform for understanding likely future developments in the area, including those associated with structure-based innovations, functional improvements, and emerging biological activation strategies.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Elementos de la Serie de los Lantanoides
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Chem Soc Rev
Año:
2022
Tipo del documento:
Article