Mutant allele knockout with novel CRISPR nuclease promotes myelopoiesis in ELANE neutropenia.

Sabo, Peter; Makaryan, Vahagn; Dicken, Yosef; Povodovski, Lital; Rockah, Liat; Bar, Tzlil; Gabay, Matan; Elinger, Dalia; Segal, Ella; Haimov, Ora; Antoshvili, Maya; Drori, Anat London; Poulsen, Tanoya; Herman, Asael; Emmanuel, Rafi; Dale, David C

Sabo, Peter; Makaryan, Vahagn; Dicken, Yosef; Povodovski, Lital; Rockah, Liat; Bar, Tzlil; Gabay, Matan; Elinger, Dalia; Segal, Ella; Haimov, Ora; Antoshvili, Maya; Drori, Anat London; Poulsen, Tanoya; Herman, Asael; Emmanuel, Rafi; Dale, David C.

Afiliación

Sabo P; Department of Medicine, University of Washington, Box 356422, 1959 NE Pacific Street, Room AA522, Seattle, WA 98195, USA.
Makaryan V; Department of Medicine, University of Washington, Box 356422, 1959 NE Pacific Street, Room AA522, Seattle, WA 98195, USA.
Dicken Y; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Povodovski L; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Rockah L; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Bar T; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Gabay M; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Elinger D; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Segal E; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Haimov O; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Antoshvili M; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Drori AL; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Poulsen T; Department of Medicine, University of Washington, Box 356422, 1959 NE Pacific Street, Room AA522, Seattle, WA 98195, USA.
Herman A; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Emmanuel R; EmendoBio, Inc., 400 W 61 Street, #2330, New York NY 10069, USA.
Dale DC; Department of Medicine, University of Washington, Box 356422, 1959 NE Pacific Street, Room AA522, Seattle, WA 98195, USA.

Mol Ther Methods Clin Dev ; 26: 119-131, 2022 Sep 08.

Article en En | MEDLINE | ID: mdl-35795780

Palabras clave

CRISPR; ELANE; allele-specific editing; gene editing; neutropenia; neutrophils

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Mol Ther Methods Clin Dev Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos