Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus.

An, Dong; Qi, Xiuting; Li, Kunpeng; Xu, Weixing; Wang, Yue; Chen, Xi; Sha, Sha; Wu, Chunfeng; Du, Yimei; Chen, Lei

An, Dong; Qi, Xiuting; Li, Kunpeng; Xu, Weixing; Wang, Yue; Chen, Xi; Sha, Sha; Wu, Chunfeng; Du, Yimei; Chen, Lei.

Afiliación

An D; Department of Physiology, Nanjing Medical University, Nanjing, People's Republic of China.
Qi X; Center for Analysis and Testing, Nanjing Medical University, Nanjing, People's Republic of China.
Li K; Department of Physiology, Nanjing Medical University, Nanjing, People's Republic of China.
Xu W; Department of Physiology, Nanjing Medical University, Nanjing, People's Republic of China.
Wang Y; Department of Physiology, Nanjing Medical University, Nanjing, People's Republic of China.
Chen X; Department of Physiology, Nanjing Medical University, Nanjing, People's Republic of China.
Sha S; Department of Physiology, Nanjing Medical University, Nanjing, People's Republic of China.
Wu C; Department of Physiology, Nanjing Medical University, Nanjing, People's Republic of China.
Du Y; Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Chen L; Research Center of Ion Channelopathy, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. yimeidu@mail.hust.edu.cn.

Cell Mol Neurobiol ; 43(3): 1283-1300, 2023 Apr.

Article en En | MEDLINE | ID: mdl-35840809

Asunto(s)

Antineoplásicos; Proteína HMGB1; Estado Epiléptico; Ratones; Animales; FN-kappa B/metabolismo; Inhibidor NF-kappaB alfa/metabolismo; Inhibidor NF-kappaB alfa/farmacología; Pilocarpina/efectos adversos; Proteína HMGB1/metabolismo; Canales Catiónicos TRPV/metabolismo; Receptor Toll-Like 4/metabolismo; Transducción de Señal; Inflamación; Estado Epiléptico/inducido químicamente

Palabras clave

Inflammatory cytokines; NF-κB signaling pathway; Neuronal injury; Temporal lobe epilepsy; Transient receptor potential vanilloid 4 (TRPV4)

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Estado Epiléptico / Proteína HMGB1 / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Mol Neurobiol Año: 2023 Tipo del documento: Article

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google