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Enhanced positive emotional reactivity in frontotemporal dementia reflects left-lateralized atrophy in the temporal and frontal lobes.
Shdo, Suzanne M; Roy, Ashlin R K; Datta, Samir; Sible, Isabel J; Lukic, Sladjana; Perry, David C; Rankin, Katherine P; Kramer, Joel H; Rosen, Howard J; Miller, Bruce L; Seeley, William W; Holley, Sarah R; Gorno-Tempini, Maria L; Sturm, Virginia E.
Afiliación
  • Shdo SM; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; University of California, Berkeley, Department of Psychology, Berkeley, CA, USA. Electronic address: shdo@berkeley.edu.
  • Roy ARK; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: ashlin.roy@ucsf.edu.
  • Datta S; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: samir.datta@ucsf.edu.
  • Sible IJ; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: jsible@usc.edu.
  • Lukic S; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: sladjana.lukic@ucsf.edu.
  • Perry DC; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: david.perry@ucsf.edu.
  • Rankin KP; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: katherine.rankin@ucsf.edu.
  • Kramer JH; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: joel.kramer@ucsf.edu.
  • Rosen HJ; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: howie.rosen@ucsf.edu.
  • Miller BL; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: bruce.miller@ucsf.edu.
  • Seeley WW; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: bill.seeley@ucsf.edu.
  • Holley SR; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; San Francisco State University, Department of Psychology, San Francisco, CA, USA. Electronic address: sholley@sfsu.edu.
  • Gorno-Tempini ML; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: marialuisa.gornotempini@ucsf.edu.
  • Sturm VE; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: virginia.sturm@ucsf.edu.
Cortex ; 154: 405-420, 2022 09.
Article en En | MEDLINE | ID: mdl-35930892
ABSTRACT
In frontotemporal dementia (FTD), left-lateralized atrophy patterns have been associated with elevations in certain positive emotions. Here, we investigated whether positive emotional reactivity was enhanced in semantic variant primary progressive aphasia (svPPA), an FTD syndrome that targets the left anterior temporal lobe. Sixty-one participants (16 people with svPPA, 24 people with behavioral variant FTD, and 21 healthy controls) viewed six 90-sec trials that were comprised of a series of photographs; each trial was designed to elicit a specific positive emotion, negative emotion, or no emotion. Participants rated their positive emotional experience after each trial, and their smiling behavior was coded with the Facial Action Coding System. Results indicated that positive emotional experience and smiling were elevated in svPPA in response to numerous affective and non-affective stimuli. Voxel-based morphometry analyses revealed that greater positive emotional experience and greater smiling in the patients were both associated with smaller gray matter volume in the left superior temporal gyrus (pFWE < .05), among other left-lateralized frontotemporal regions. Whereas enhanced positive emotional experience related to atrophy in middle superior temporal gyrus and structures that promote cognitive control and emotion regulation, heightened smiling related to atrophy in posterior superior temporal gyrus and structures that support motor control. Our results suggest positive emotional reactivity is elevated in svPPA and offer new evidence that atrophy in left-lateralized emotion-relevant systems relates to enhanced positive emotions in FTD.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Pick / Demencia Frontotemporal Límite: Humans Idioma: En Revista: Cortex Año: 2022 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Pick / Demencia Frontotemporal Límite: Humans Idioma: En Revista: Cortex Año: 2022 Tipo del documento: Article